The 3′-untranslated region of the Ste20-like kinase SLK regulates SLK expression
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چکیده
منابع مشابه
The 3'-untranslated region of the Ste20-like kinase SLK regulates SLK expression.
Ste20-like kinase, SLK, a germinal center kinase found in kidney epithelial cells, signals to promote apoptosis. Expression of SLK mRNA and protein and kinase activity are increased during kidney development and recovery from ischemic acute renal failure. The 3'-untranslated region (3'-UTR) of SLK mRNA contains multiple adenine and uridine-rich elements, suggesting that 3'-UTR may regulate mRNA...
متن کاملThe Ste20-like kinase SLK promotes p53 transactivation and apoptosis.
Expression and activity of the germinal center kinase [corrected] SLK are increased during kidney development and recovery from renal ischemia-reperfusion injury. SLK promotes apoptosis, in part, via pathway(s) involving apoptosis signal-regulating kinase-1 and p38 mitogen-activated protein kinase. This study addresses the role of p53 as a potential effector of SLK. p53 transactivation was meas...
متن کاملSte20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome
The microtubule- and centrosome-associated Ste20-like kinase (SLK; long Ste20-like kinase [LOSK]) regulates cytoskeleton organization and cell polarization and spreading. Its inhibition causes microtubule disorganization and release of centrosomal dynactin. The major function of dynactin is minus end-directed transport along microtubules in a complex with dynein motor. In addition, dynactin is ...
متن کاملv-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II.
We have previously shown that the Ste20-like kinase SLK is a microtubule-associated protein inducing actin stress fiber disassembly. Here, we show that v-Src expression can down-regulate SLK activity. This down-regulation is independent of focal adhesion kinase but requires v-Src kinase activity and membrane translocation. SLK down-regulation by v-Src is indirect and is accompanied by SLK hyper...
متن کاملActivity of the Ste20-like kinase, SLK, is enhanced by homodimerization.
The expression and activation of the Ste20-like kinase, SLK, is increased during renal development and recovery from ischemic acute renal failure. SLK promotes apoptosis, and during renal injury and repair, transcriptional induction or posttranscriptional control of SLK may, therefore, regulate cell survival. SLK contains protein interaction (coiled-coil) domains, suggesting that posttranslatio...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2007
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00234.2006